Code | CSB-EP768237HU |
MSDS | |
Size | $224 |
Order now | |
Image | |
Have Questions? | Leave a Message or Start an on-line Chat |
Review: Lypd6 reversibly attenuates nAChR-induced membrane responses in CA1 hippocampal interneurons.Whole-cell voltage clamp recordings from a CA1 interneuron showing no effect on induction of inward current by application of Lypd6. (c) An example of whole-cell voltage clamp recordings from a CA1 interneuron showing induction of inward current by application of nicotine (arrow) and attenuation of this current when applied in the presence of Lypd6 (Nic + Lypd6). Nicotine responses were not attenuated with a 3-min interval between applications, indicating that reductions induced in the presence of Lypd6 were not because of cell run down, but were specific to the presence of the protein. (d) An example of whole-cell voltage clamp recordings from a CA1 interneuron, pre-incubated in Lypd6 for 5 min before first application of nicotine, showing that the effect of Lypd6 is lost upon wash-out. The recording examples shown in (c) and (d) are not representing the mean values, but were rather chosen as high- amplitude samples to clearly demonstrate the inhibitory effect of Lypd6.
By Anonymous